| + |
ASTN2 | up-regulates 
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269814 |
|
|
Homo sapiens |
Brain |
| pmid |
sentence |
| 28506896 |
The role of astrotactin and Brinp proteins has been partially characterized, with ASTN1 and ASTN2 demonstrated to facilitate glial-guided neuronal migration during brain development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBA1B | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269727 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBA1A | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269725 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBA3D | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269723 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBA4A | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269730 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBA3E | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269726 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Microtubule_polimerization | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266829 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28347630 |
Microtubules are essential for the generation, migration and differentiation of neurons. Within dendrites microtubules have also been implicated in the formation and plasticity of spines. For instance, the treatment of hippocampal neurons with low doses of the microtubule destabilizing drug Nocodazole impairs BDNF induced dendritic spine formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AUTS2 | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266816 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28505103 |
Cytoplasmic AUTS2 regulates actin cytoskeleton to control neuronal migration and neurite extension, while nuclear AUTS2 controls transcription of various genes as a component of the polycomb complex 1 (PRC1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAFAH1B1 | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252169 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20133715 |
The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBA8 | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269729 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBA1C | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269728 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ASTN1 | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269815 |
|
|
Homo sapiens |
Brain |
| pmid |
sentence |
| 28506896 |
The role of astrotactin and Brinp proteins has been partially characterized, with ASTN1 and ASTN2 demonstrated to facilitate glial-guided neuronal migration during brain development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBA3C | up-regulates
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269724 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Neuron_migration