Relation Results

Summary

Name Neuron_migration
Primary ID SIGNOR-PH67
Type phenotype
Description The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
Relations 13

Viewer

Type: Score: Layout: SPV 
0.70.70.70.70.70.70.70.70.70.70.70.70.7TUBA3ENeuron_migrationTUBA1CTUBA1ATUBA4AASTN2TUBA1BMicrotubule_polimerizationAUTS2ASTN1PAFAH1B1TUBA8TUBA3CTUBA3D

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ TUBA3Eup-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269726 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching.
Publications: 1 Organism: Homo Sapiens
+ TUBA1Cup-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269728 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching.
Publications: 1 Organism: Homo Sapiens
+ TUBA1Aup-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269725 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching.
Publications: 1 Organism: Homo Sapiens
+ TUBA4Aup-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269730 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching.
Publications: 1 Organism: Homo Sapiens
+ ASTN2up-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269814 Homo sapiens Brain
pmid sentence
The role of astrotactin and Brinp proteins has been partially characterized, with ASTN1 and ASTN2 demonstrated to facilitate glial-guided neuronal migration during brain development
Publications: 1 Organism: Homo Sapiens
+ TUBA1Bup-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269727 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching.
Publications: 1 Organism: Homo Sapiens
+ Microtubule_polimerizationup-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-266829 Homo sapiens
pmid sentence
Microtubules are essential for the generation, migration and differentiation of neurons. Within dendrites microtubules have also been implicated in the formation and plasticity of spines. For instance, the treatment of hippocampal neurons with low doses of the microtubule destabilizing drug Nocodazole impairs BDNF induced dendritic spine formation
Publications: 1 Organism: Homo Sapiens
+ AUTS2up-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-266816 Homo sapiens
pmid sentence
Cytoplasmic AUTS2 regulates actin cytoskeleton to control neuronal migration and neurite extension, while nuclear AUTS2 controls transcription of various genes as a component of the polycomb complex 1 (PRC1).
Publications: 1 Organism: Homo Sapiens
+ ASTN1up-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269815 Homo sapiens Brain
pmid sentence
The role of astrotactin and Brinp proteins has been partially characterized, with ASTN1 and ASTN2 demonstrated to facilitate glial-guided neuronal migration during brain development
Publications: 1 Organism: Homo Sapiens
+ PAFAH1B1up-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-252169 Homo sapiens
pmid sentence
The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration.
Publications: 1 Organism: Homo Sapiens
+ TUBA8up-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269729 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching.
Publications: 1 Organism: Homo Sapiens
+ TUBA3Cup-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269724 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching.
Publications: 1 Organism: Homo Sapiens
+ TUBA3Dup-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269723 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching.
Publications: 1 Organism: Homo Sapiens
a simple tooltip