Relation Results

Summary

Name RHOU
Full Name Rho-related GTP-binding protein RhoU
Synonyms CDC42-like GTPase 1, GTP-binding protein-like 1, Rho GTPase-like protein ARHU, Ryu GTPase, Wnt-1 responsive Cdc42 homolog 1, WRCH-1 | ARHU, CDC42L1, G28K, WRCH1
Primary ID Q7L0Q8
Links - -
Type protein
Relations 1
Function Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cel ...
View More

Viewer

Type: Score: Layout: SPV 
0.534SRCRHOU

Modifications Tables

Relations

Regulator
Mechanism
target
score
+ down-regulates activity img/direct_inhibition.png phosphorylation RHOU 0.534
Identifier Residue Sequence Organism Cell Line
SIGNOR-259814 Tyr254 SKSWWKKyCCFV Homo sapiens NCI-H1299 Cell
pmid sentence
Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src. Phosphorylation at Y254 negatively regulates Wrch-1-mediated biological functions.Serum-stimulated tyrosine phosphorylation and relocalization of Wrch-1 decreases its activation of downstream effectors in a Y254-dependent manner.
Publications: 1 Organism: Homo Sapiens
a simple tooltip