| + |
JMJD6 | down-regulates activity 
cleavage
|
MEPCE |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261037 |
Arg171 |
HPAFKRRrRVNSDCD |
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 32048991 |
JMJD6 cleaves MePCE. we propose that JMJD6 is the cognate protease of MePCE and cleaves at the R171 site within MePCE. Experiments using purified JMJD6 showed that it could make a cut in an enzyme called MePCE, which belongs to the group of proteins that hold P-TEFb in its inactive form. The levels of activated Pol II were lower in cells without JMJD6 and higher in those without MePCE. Together, the results suggest that JMJD6 cuts MePCE to release P-TEFb, which then activates Pol II. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MEPCE | down-regulates activity
binding
|
P-TEFb |
0.565 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261038 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 32048991 |
JMJD6 cleaves MePCE. we propose that JMJD6 is the cognate protease of MePCE and cleaves at the R171 site within MePCE. Experiments using purified JMJD6 showed that it could make a cut in an enzyme called MePCE, which belongs to the group of proteins that hold P-TEFb in its inactive form. The levels of activated Pol II were lower in cells without JMJD6 and higher in those without MePCE. Together, the results suggest that JMJD6 cuts MePCE to release P-TEFb, which then activates Pol II. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
MEPCE
- 
- 