| + |
RRAGA | form complex 
binding
|
RAGAC |
0.77 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228164 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20381137 |
Mammals express four Rag proteinsRagA, RagB, RagC, and RagDthat form heterodimers consisting of RagA or RagB with RagC or RagD. RagA and RagB, like RagC and RagD, are highly similar to each other and are functionally redundant |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAGAC | up-regulates activity 
relocalization
|
MTOR |
0.804 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228657 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20381137 |
The Rag GTPases interact with mTORC1 and are proposed to activate it in response to amino acids by promoting mTORC1 translocation to a membrane-bound compartment that contains the mTORC1 activator, Rheb |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | MTOR Signaling |
| + |
RRAGC | form complex
binding
|
RAGAC |
0.77 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228161 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20381137 |
Mammals express four Rag proteinsRagA, RagB, RagC, and RagDthat form heterodimers consisting of RagA or RagB with RagC or RagD. RagA and RagB, like RagC and RagD, are highly similar to each other and are functionally redundant |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAGAC | up-regulates activity
relocalization
|
mTORC1 |
0.677 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228158 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20381137 |
The Rag GTPases interact with mTORC1 and are proposed to activate it in response to amino acids by promoting mTORC1 translocation to a membrane-bound compartment that contains the mTORC1 activator, Rheb |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mTOR in cancer |
| + |
LAMTOR | up-regulates activity
relocalization
|
RAGAC |
0.874 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228155 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20381137 |
We identify the trimeric Ragulator protein complex as a new component of the mTORC1 pathway that interacts with the Rag GTPases, is essential for localizing them and mTORC1 to the lysosomal surface, and is necessary for the activation of the mTORC1 pathway by amino acids. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mTOR in cancer, MTOR Signaling |
3.0
RAGAC
CPX-2542