Relation Results

Summary

Name H2AW
Full Name Histone H2A type 3
Synonyms H2A3_HUMAN | HIST3H2A
Primary ID Q7L7L0
Links - -
Type protein
Relations 3
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DN ...
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Type: Score: Layout: SPV 
0.20.20.2DZIP3H2AWRPS6KA5SLBP

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ DZIP3up-regulates activity img/direct-activation.png monoubiquitination H2AW 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271757 Lys119 IQAVLLPkKTESHHK Homo sapiens HEK-293 Cell
pmid sentence
 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA5up-regulates activity img/direct-activation.png phosphorylation H2AW 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262942 Ser2 sGRGKQGG in vitro
pmid sentence
We found that MSK1 phosphorylated histone H2A on serine 1, and mutation of serine 1 to alanine blocked the inhibition of transcription by MSK1. Furthermore, we found that acetylation of histone H3 by the p300 and CREB-binding protein associated factor, PCAF, suppressed the kinase-dependent inhibition of transcription. These results suggest that acetylation of histones may stimulate transcription by suppressing an inhibitory phosphorylation by a kinase as MSK1.
Publications: 1 Organism: In Vitro
+ SLBPup-regulates quantity by expression img/direct-activation.png translation regulation H2AW 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265409 Homo sapiens U2-OS Cell
pmid sentence
Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cytoplasm, where SLBP participates in translation of the histone mRNA|We used radiolabeled probes generated by PCR targeting the open reading frame (ORF) to detect histones H2A, H2B, H3, H4, and H1 and used 7SK snRNA as a loading control (Fig. 2A). The abundance of histone H2A, H2B, H3, and H4 mRNAs is reduced to 37% to 70% of control levels in the SLBP knockdown cells when compared to the C2 control.
Publications: 1 Organism: Homo Sapiens
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