| + |
DZIP3 | up-regulates activity 
monoubiquitination
|
H2AX |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271752 |
Lys119 |
IQAVLLPkKTSATVG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AW |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271757 |
Lys119 |
IQAVLLPkKTESHHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AC12 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271760 |
Lys119 |
IQAVLLPkKTESHHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271761 |
Lys119 |
IQAVLLPkKTESHHH |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AC7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271753 |
Lys119 |
IQAVLLPkKTESHHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271747 |
Lys119 |
IQAVLLPkKTESHHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AC11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271749 |
Lys119 |
IQAVLLPkKTESHHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AC6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271759 |
Lys119 |
IQAVLLPkKTESHHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AC14 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271762 |
Lys119 |
IQAVLLPkKTESHHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AC18 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271755 |
Lys119 |
IQAVLLPkKTESHHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AJ |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271763 |
Lys119 |
IQAVLLPkKTESQKT |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AC20 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271754 |
Lys119 |
IQAVLLPkKTESHKA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AC21 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271758 |
Lys119 |
IQAVLLPkKTESHKP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AZ2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271756 |
Lys121 |
IHKSLIGkKGQQKTA |
Homo sapiens |
|
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | up-regulates activity
monoubiquitination
|
H2AZ1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271748 |
Lys121 |
IHKSLIGkKGQQKTV |
Homo sapiens |
|
| pmid |
sentence |
| 18206970 |
2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOTAIR | up-regulates activity
binding
|
DZIP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272091 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24326307 |
HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity
ubiquitination
|
DZIP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271191 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DZIP3 | down-regulates quantity by destabilization 
polyubiquitination
|
ATXN1 |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272078 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24326307 |
HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DZIP3
- 
- 