3.0
Summary
| Name |  ZC3HAV1
|
| Full Name | Zinc finger CCCH-type antiviral protein 1 |
| Synonyms | ADP-ribosyltransferase diphtheria toxin-like 13, ARTD13, Inactive Poly [ADP-ribose] polymerase 13, PARP13, Zinc finger CCCH domain-containing protein 2, Zinc finger antiviral protein, ZAP | ZC3HDC2 |
| Primary ID | Q7Z2W4 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae |
binding