3.0
Summary
| Name |  ZC3HAV1View Modifications |
| Full Name | Zinc finger CCCH-type antiviral protein 1 |
| Synonyms | ADP-ribosyltransferase diphtheria toxin-like 13, ARTD13, Inactive Poly [ADP-ribose] polymerase 13, PARP13, Zinc finger CCCH domain-containing protein 2, Zinc finger antiviral protein, ZAP | ZC3HDC2 |
| Primary ID | Q7Z2W4 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GSK3B | up-regulates activity 
phosphorylation
|
ZC3HAV1 | |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | ZC3HAV1 | up-regulates activity
binding
|
PARN | 0.422 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM25 | up-regulates activity
ubiquitination
|
ZC3HAV1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |