| + |
KANSL1 | up-regulates 
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267172 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26243146 |
Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KANSL1 | form complex 
binding
|
NSL histone acetyltransferase |
0.658 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267164 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KANSL1 | up-regulates
|
Microtubule_polimerization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267170 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26243146 |
Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
KANSL1
- 
- 