| + |
NSL histone acetyltransferase | down-regulates activity 
acetylation
|
H4C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267166 |
Lys17 |
GLGKGGAkRHRKVLR |
Homo sapiens |
|
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. by comparing the substrate specificities of the MSL and NSL complexes, we obtain evidence that MOF HAT activity is differentially regulated by assembly into the MSL complex, where it acetylates nucleosomal histone H4 on lysine 16, and the NSL complex, where it also acetylates nucleosomal histone H4 on lysines 5 and 8. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267167 |
Lys6 |
kGGKGLGK |
Homo sapiens |
|
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. by comparing the substrate specificities of the MSL and NSL complexes, we obtain evidence that MOF HAT activity is differentially regulated by assembly into the MSL complex, where it acetylates nucleosomal histone H4 on lysine 16, and the NSL complex, where it also acetylates nucleosomal histone H4 on lysines 5 and 8. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267168 |
Lys9 |
SGRGKGGkGLGKGGA |
Homo sapiens |
|
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. by comparing the substrate specificities of the MSL and NSL complexes, we obtain evidence that MOF HAT activity is differentially regulated by assembly into the MSL complex, where it acetylates nucleosomal histone H4 on lysine 16, and the NSL complex, where it also acetylates nucleosomal histone H4 on lysines 5 and 8. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MCRS1 | form complex 
binding
|
NSL histone acetyltransferase |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267161 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT8 | form complex
binding
|
NSL histone acetyltransferase |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267160 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HCFC1 | form complex
binding
|
NSL histone acetyltransferase |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267165 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KANSL2 | form complex
binding
|
NSL histone acetyltransferase |
0.655 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267163 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WDR5 | form complex
binding
|
NSL histone acetyltransferase |
0.648 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267157 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KANSL3 | form complex
binding
|
NSL histone acetyltransferase |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267162 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OGT | form complex
binding
|
NSL histone acetyltransferase |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267158 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KANSL1 | form complex
binding
|
NSL histone acetyltransferase |
0.658 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267164 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF20 | form complex
binding
|
NSL histone acetyltransferase |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267159 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NSL histone acetyltransferase
CPX-809