| + |
SMC5/6 | up-regulates 
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265488 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27427983 |
The SMC5/6 complex, consisting of SMC5, SMC6, and non-SMC elements NSMCE1–6, has key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability. In particular, the SMC5/6 complex is involved in resolving intermediates during recombination (5, 6) and other complex DNA structures, such as stalled replication forks |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHAMP1 | up-regulates
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264901 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21063390 |
Proper attachment of microtubules to kinetochores is essential for accurate chromosome segregation. These data suggest that CAMP is required for maintaining kinetochore-microtubule attachment during biorientation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KMN network | up-regulates
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265220 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18007590 |
Based on our results, we propose that the cooperative action of CENP-A NAC/CAD subunits and the KMN network drives efficient chromosome segregation and bipolar spindle assembly during mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDLBP | up-regulates
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266695 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33941620 |
Vigilin (Vgl1) is essential for heterochromatin formation, chromosome segregation, and mRNA stability and is associated with autism spectrum disorders and cancer: vigilin, for example, can suppress proto-oncogene c-fms expression in breast cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CPC | up-regulates
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275427 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 37292983 |
Here, we focus on the chromosome passenger complex (CPC), that forms a chromatin body that regulates chromosome segregation in mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cohesin complex | up-regulates
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264523 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30544080 |
Cohesin, one of structural maintenance of chromosomes (SMC) complexes, forms a ring-shaped protein complex, and mediates sister chromatid cohesion for accurate chromosome segregation and precise genome inheritance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KANSL3 | up-regulates
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267171 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26243146 |
Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCAN complex | up-regulates
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265219 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18007590 |
Based on our results, we propose that the cooperative action of CENP-A NAC/CAD subunits and the KMN network drives efficient chromosome segregation and bipolar spindle assembly during mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TOP2A | up-regulates
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242530 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20562910 |
Topoisomerase IIalpha (topoIIalpha) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KANSL1 | up-regulates
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267172 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26243146 |
Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Chromosome_segregation