Summary

Name CLASP1
Full Name CLIP-associating protein 1
Synonyms Cytoplasmic linker-associated protein 1, Multiple asters homolog 1, Protein Orbit homolog 1, hOrbit1 | KIAA0622, MAST1
Primary ID Q7Z460
Links - -
Type protein
Relations 4
Function Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

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Relations

Regulator Mechanism target score ℹ
+ CLASP1up-regulates activity img/direct-activation.png binding CLIP1 0.715
Publications: 1 Organism: Homo Sapiens
+ CLASP1up-regulates activity img/direct-activation.png binding MAPRE1 0.593
Publications: 1 Organism: Homo Sapiens
+ CLASP1up-regulates activity img/direct-activation.png binding CLIP2 0.613
Publications: 1 Organism: Homo Sapiens
+ TPX2up-regulates activity img/direct-activation.png binding CLASP1 0.477
Publications: 1 Organism: Homo Sapiens