Relation Results

Summary

Name MAPRE1
Full Name Microtubule-associated protein RP/EB family member 1
Synonyms APC-binding protein EB1, End-binding protein 1, EB1
Primary ID Q15691
Links - -
Type protein
Relations 5
Function Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:1238876 ...
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Type: Score: Layout: SPV 
0.20.630.6070.20.7SRCMAPRE1CLASP2CLASP1CEP43Microtubule_polimerization

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ SRCdown-regulates activity img/direct_inhibition.png phosphorylation MAPRE1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278215 Tyr247 QRIVDILyATDEGFV Homo sapiens
pmid sentence
These data suggest that Src phosphorylates endogenous EB1 at Y247.
Publications: 1 Organism: Homo Sapiens
+ CLASP2up-regulates activity img/direct-activation.png binding MAPRE1 0.63
Identifier Residue Sequence Organism Cell Line
SIGNOR-264829 Chlorocebus aethiops COS Cell
pmid sentence
GSK-3beta directly phosphorylates CLASP2 at Ser533 and Ser537 within the region responsible for the IQGAP1 binding. Phosphorylation of CLASP2 results in the dissociation of CLASP2 from IQGAP1, EB1 and microtubules.| CLASPs were originally identified as CLIP-170-interacting proteins and later found to be required for microtubule stabilisation at the cortical regions of epithelial cells
Publications: 1 Organism: Chlorocebus Aethiops
+ CLASP1up-regulates activity img/direct-activation.png binding MAPRE1 0.607
Identifier Residue Sequence Organism Cell Line
SIGNOR-265094 Homo sapiens HeLa Cell
pmid sentence
CLIP-associating protein (CLASP) 1 and CLASP2 are mammalian microtubule (MT) plus-end binding proteins, which associate with CLIP-170 and CLIP-115.|We demonstrate that the middle part of CLASPs binds directly to EB1 and to MTs. | Both EB1- and cortex-binding domains of CLASP are required to promote MT stability.
Publications: 1 Organism: Homo Sapiens
+ CEP43up-regulates img/direct-activation.png relocalization MAPRE1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-142400 Homo sapiens
pmid sentence
Fop also binds to eb1 and is required for localizing eb1 to the centrosome
Publications: 1 Organism: Homo Sapiens
+ MAPRE1up-regulates img/direct-activation.png binding Microtubule_polimerization 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264831
pmid sentence
Microtubule plus end binding proteins (+TIPs) localize to the dynamic plus ends of microtubules, where they stimulate microtubule growth and recruit signaling molecules. Three main +TIP classes have been identified (XMAP215, EB1, and CLIP-170)
Publications: 1
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