| + |
MDGA2 | up-regulates quantity by expression 
transcriptional regulation
|
CDKN1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264242 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26206665 |
Enhanced protein expression of p53 and p21 by MDGA2 was confirmed in MDGA2 overexpressed cells and xenograft tumours. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDGA2 | up-regulates quantity by stabilization 
binding
|
DMAP1 |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264240 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26206665 |
The anti-tumorigenic effect of MDGA2 was mediated through direct stabilising of DNA methyltransferase 1 associated protein 1 (DMAP1), which played a tumour suppressive role in gastric cancer. MDGA2 expression and MG132 treatment increased the level of DMAP1, suggesting that the MDGA2–DMAP1 interaction stabilises DMAP1 by inhibiting its ubiquitin-mediated degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDGA2 | up-regulates quantity by expression
transcriptional regulation
|
TP53 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264241 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26206665 |
Enhanced protein expression of p53 and p21 by MDGA2 was confirmed in MDGA2 overexpressed cells and xenograft tumours. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDGA2 | down-regulates 
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264239 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26206665 |
MDGA2 acts as a novel tumour suppressor in gastric cancer through inhibiting cell proliferation, suppressing G1–S cell cycle transition and inducing cell apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MDGA2
- 
- 