3.0
Summary
| Name |  ARHGAP22View Modifications |
| Full Name | Rho GTPase-activating protein 22 |
| Synonyms | Rho-type GTPase-activating protein 22 | RHOGAP2 |
| Primary ID | Q7Z5H3 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT | up-regulates activity 
phosphorylation
|
ARHGAP22 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARHGAP22 | down-regulates activity 
gtpase-activating protein
|
RAC1 | 0.505 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARHGAP22 | down-regulates activity
gtpase-activating protein
|
RHOA | 0.543 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARHGAP22 | down-regulates activity
gtpase-activating protein
|
CDC42 | 0.52 |
| Publications: | 1 | Organism: | Homo Sapiens | |