Relation Results

Summary

Name RBBP6
Full Name E3 ubiquitin-protein ligase RBBP6
Synonyms Proliferation potential-related protein, Protein P2P-R, RING-type E3 ubiquitin transferase RBBP6, Retinoblastoma-binding Q protein 1, RBQ-1, Retinoblastoma-binding protein 6, p53-associated cellular protein of testis | P2PR, PACT, RBQ1
Primary ID Q7Z6E9
Links - -
Type protein
Relations 3
Function E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as ...
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Type: Score: Layout: SPV 
0.20.3180.425Ub:E2RBBP6YBX1ZBTB38

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Relations
Regulator
Mechanism
target
score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RBBP6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271183 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
+ RBBP6down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination YBX1 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-271773 Homo sapiens
pmid sentence
RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1
Publications: 1 Organism: Homo Sapiens
+ RBBP6down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ZBTB38 0.425
Identifier Residue Sequence Organism Cell Line
SIGNOR-278594 Homo sapiens
pmid sentence
Thus, RBBP6 induces ZBTB38 protein degradation, and this depends on the activity of the proteasome.We next tested whether RBBP6 might directly ubiquitinate ZBTB38.|We show that ZBTB38 is directly ubiquitinated by RBBP6 in human and mouse cells, in a process that is independent of p53 and MDM2, and leads to proteasomal degradation.
Publications: 1 Organism: Homo Sapiens
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