| + |
SIAH1 | down-regulates quantity by destabilization 
ubiquitination
|
YBX1 |
0.243 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278780 |
Lys304 |
PQDGKETkAADPPAE |
Homo sapiens |
|
| pmid |
sentence |
| 35273154 |
Here, we identified that SIAH1 which was downregulated in chemoresistant EOC samples and cell lines functioned as novel E3 ligases to trigger degradation of YBX-1 at cytoplasm by RING finger domain.|SIAH1 ubiquitinated YBX-1 at its K304 through the RING domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | up-regulates 
phosphorylation
|
YBX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182493 |
Ser102 |
NPRKYLRsVGDGETV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19036157 |
Phosphorylation of yb-1 at the serine 102 residue is required for transcriptional activation of growth-enhancing genes, such as egfr. Herein, we illustrate that activated akt binds to and phosphorylates the yb-1 cold shock domain at ser102 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates
phosphorylation
|
YBX1 |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252475 |
Ser102 |
NPRKYLRsVGDGETV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15806160 |
Phosphorylation of yb-1 at the serine 102 residue is required for transcriptional activation of growth-enhancing genes, such as egfr. Herein, we illustrate that activated akt binds to and phosphorylates the yb-1 cold shock domain at ser102 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252521 |
Ser102 |
NPRKYLRsVGDGETV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19036157 |
Phosphorylation of yb-1 at the serine 102 residue is required for transcriptional activation of growth-enhancing genes, such as egfr. Herein, we illustrate that activated akt binds to and phosphorylates the yb-1 cold shock domain at ser102 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RPS6K | up-regulates
phosphorylation
|
YBX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252804 |
Ser102 |
NPRKYLRsVGDGETV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19036157 |
We therefore conclude that rsk1/rsk2 are novel activators of yb-1, able to phosphorylate the serine 102 residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA1 | up-regulates
phosphorylation
|
YBX1 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182497 |
Ser102 |
NPRKYLRsVGDGETV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19036157 |
We therefore conclude that rsk1/rsk2 are novel activators of yb-1, able to phosphorylate the serine 102 residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA3 | up-regulates
phosphorylation
|
YBX1 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182165 |
Ser102 |
NPRKYLRsVGDGETV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19036157 |
We therefore conclude that rsk1/rsk2 are novel activators of yb-1, able to phosphorylate the serine 102 residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK1 | up-regulates quantity
phosphorylation
|
YBX1 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279254 |
Ser174 |
SGEKNEGsESAPEGQ |
Homo sapiens |
|
| pmid |
sentence |
| 36805592 |
Here we identify that PLK1 inhibition can induce apoptosis and DNA damage of GSCs, we have also delineat the possible underlying molecular mechanisms: PLK1 interacts with YBX1 and directly phosphorylates serine 174 and serine 176 of YBX1.|Inhibition of PLK1 reduces the phosphorylation level of YBX1, and decreased phosphorylation of YBX1 prevents its nuclear translocation, thereby inducing apoptosis and DNA damage of GSCs. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279255 |
Ser176 |
EKNEGSEsAPEGQAQ |
Homo sapiens |
|
| pmid |
sentence |
| 36805592 |
Here we identify that PLK1 inhibition can induce apoptosis and DNA damage of GSCs, we have also delineat the possible underlying molecular mechanisms: PLK1 interacts with YBX1 and directly phosphorylates serine 174 and serine 176 of YBX1.|Inhibition of PLK1 reduces the phosphorylation level of YBX1, and decreased phosphorylation of YBX1 prevents its nuclear translocation, thereby inducing apoptosis and DNA damage of GSCs. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKDC | up-regulates activity
phosphorylation
|
YBX1 |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277611 |
Thr89 |
EDVFVHQtAIKKNNP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 36475703 |
The DNA-PK subunits and YB-1 phosphorylated at T89 were found colocalized suggesting their in vivo interaction.DNA-PK directly phosphorylates YB-1 and, this way, modulates YB-1 function. Point mutation of YB-1 at this residue abrogated the translocation of YB-1 into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YBX1 | down-regulates quantity by repression 
transcriptional regulation
|
TYMS |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255613 |
|
|
Homo sapiens |
Ovary Cancer Cell |
| pmid |
sentence |
| 17072343 |
YB-1 knockdown by siRNA upregulated 344 genes, including MDR1, thymidylate synthetase, S100 calcium binding protein and cyclin B, and downregulated 534 genes, including CXCR4, N-myc downstream regulated gene 1, E-cadherin and phospholipase C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-betaTRCP | down-regulates quantity by destabilization
polyubiquitination
|
YBX1 |
0.321 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271606 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16797541 |
Here we identify FBX33 as a component of an SCF E3-ubiquitin ligase that targets the multifunctional regulator Y-box binding protein 1 (YB-1)/dbpB/p50 for polyubiquitination and destruction by the proteasome. By targeting YB-1 for proteasomal degradation, FBX33 negatively interferes with YB-1 mediated functions. FBX33 recruits Skp-1/Cul1 to YB-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YBX1 | up-regulates quantity by expression 
transcriptional regulation
|
ABCB1 |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253873 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10644769 |
these results indicate a role for both NF-Y and Sp1 in the transcriptional activation of the MDR1 gene by genotoxic stress, and indicate that YB-1, if involved, is not sufficient to mediate this activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBBP6 | down-regulates quantity by destabilization
ubiquitination
|
YBX1 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271773 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18851979 |
RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YBX1 | up-regulates quantity by expression
transcriptional regulation
|
CXCR4 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255611 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17072343 |
YB-1 knockdown by siRNA upregulated 344 genes, including MDR1, thymidylate synthetase, S100 calcium binding protein and cyclin B, and downregulated 534 genes, including CXCR4, N-myc downstream regulated gene 1, E-cadherin and phospholipase C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO33 | down-regulates quantity by destabilization
binding
|
YBX1 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271604 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16797541 |
Here we identify FBX33 as a component of an SCF E3-ubiquitin ligase that targets the multifunctional regulator Y-box binding protein 1 (YB-1)/dbpB/p50 for polyubiquitination and destruction by the proteasome. By targeting YB-1 for proteasomal degradation, FBX33 negatively interferes with YB-1 mediated functions. FBX33 recruits Skp-1/Cul1 to YB-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YBX1 | up-regulates quantity by expression
transcriptional regulation
|
CDH1 |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255610 |
|
|
Homo sapiens |
Ovary Cancer Cell |
| pmid |
sentence |
| 17072343 |
YB-1 knockdown by siRNA upregulated 344 genes, including MDR1, thymidylate synthetase, S100 calcium binding protein and cyclin B, and downregulated 534 genes, including CXCR4, N-myc downstream regulated gene 1, E-cadherin and phospholipase C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YBX1 | down-regulates quantity by repression
transcriptional regulation
|
ABCB1 |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255614 |
|
|
Homo sapiens |
Ovary Cancer Cell |
| pmid |
sentence |
| 17072343 |
YB-1 knockdown by siRNA upregulated 344 genes, including MDR1, thymidylate synthetase, S100 calcium binding protein and cyclin B, and downregulated 534 genes, including CXCR4, N-myc downstream regulated gene 1, E-cadherin and phospholipase C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECP2 | up-regulates activity
binding
|
YBX1 |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277700 |
|
|
|
|
| pmid |
sentence |
| 16251272 |
In this study, we show that MeCP2 interacts with the RNA-binding protein Y box-binding protein 1 and regulates splicing of reporter minigenes. Importantly, we found aberrant alternative splicing patterns in a mouse model of RTT. Thus, we uncovered a previously uncharacterized function of MeCP2 that involves regulation of splicing, in addition to its role as a transcriptional repressor. |
|
| Publications: |
1 |
| + |
YBX1 | down-regulates quantity by repression
transcriptional regulation
|
MMP13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255615 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17822788 |
YB-1 binds to the MMP-13 promoter sequence and represses MMP-13 transactivation via the AP-1 site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | up-regulates activity
phosphorylation
|
YBX1 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279227 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19036157 |
ERK2 may also directly phosphorylate YB-1 and therefore promotes its ability to transactivate target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YBX1 | up-regulates quantity by expression
transcriptional regulation
|
NDRG1 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255612 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17072343 |
YB-1 knockdown by siRNA upregulated 344 genes, including MDR1, thymidylate synthetase, S100 calcium binding protein and cyclin B, and downregulated 534 genes, including CXCR4, N-myc downstream regulated gene 1, E-cadherin and phospholipase C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
YBX1
- 
- 