3.0
Summary
| Name |  PIP4P1
|
| Full Name | Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase |
| Synonyms | Type 1 PtdIns-4,5-P2 4-Ptase, EC 3.1.3.78, PtdIns-4,5-P2 4-Ptase I, Transmembrane protein 55B | C14orf9, TMEM55B |
| Primary ID | Q86T03 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345). {ECO:0000269|PubMed:16365287, ECO:0000269|PubMed:25035345, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:29644770}. |
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transcriptional regulation