| + |
MAPK1 | up-regulates activity 
phosphorylation
|
RSPH3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262839 |
Thr243 |
QEQLRPQtPEPVEGR |
Homo sapiens |
|
| pmid |
sentence |
| 19684019 |
ERK1/2 phosphorylate RSPH3. the extent of radiolabeled phosphate incorporation into RSPH3 T286A was much less than that into wild-type RSPH3, suggesting that threonine 286 is the major ERK1/2 phosphorylation site in cells. ERK2 also phosphorylates RSPH3 on threonine 243 to a lesser extent. Phosphorylation of the double mutant T243V/T286A RSPH3 was no more than 20% that of wild-type RSPH3 (Fig. 4, C and D). inhibiting ERK1/2 activity appears to negatively regulate the AKAP function of RSPH3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262838 |
Thr286 |
AFLDRPPtPLFIPAK |
Homo sapiens |
|
| pmid |
sentence |
| 19684019 |
ERK1/2 phosphorylate RSPH3. the extent of radiolabeled phosphate incorporation into RSPH3 T286A was much less than that into wild-type RSPH3, suggesting that threonine 286 is the major ERK1/2 phosphorylation site in cells. ERK2 also phosphorylates RSPH3 on threonine 243 to a lesser extent. Phosphorylation of the double mutant T243V/T286A RSPH3 was no more than 20% that of wild-type RSPH3 (Fig. 4, C and D). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
RSPH3
- 
- 