Summary

Name TSPAN33
Full Name Tetraspanin-33
Synonyms Tspan-33, Penumbra, hPen, Proerythroblast new membrane | PEN
Primary ID Q86UF1
Links - -
Type protein
Relations 3
Function Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011).

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Relations

Regulator Mechanism target score ℹ
+ PLEKHA7up-regulates activity img/direct-activation.png binding TSPAN33 0.409
Publications: 1 Organism: Rattus Norvegicus
+ PDZD11up-regulates activity img/direct-activation.png binding TSPAN33 0.333
Publications: 1 Organism: Rattus Norvegicus
+ TSPAN33up-regulates activity img/direct-activation.png binding ADAM10 0.496
Publications: 1 Organism: Rattus Norvegicus