Summary

Name PPP1R3B
Full Name Protein phosphatase 1 regulatory subunit 3B
Synonyms Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL, Protein phosphatase 1 regulatory subunit 4, PP1 subunit R4, Protein phosphatase 1 subunit GL, PTG | PPP1R4
Primary ID Q86XI6
Links - -
Type protein
Relations 4
Function Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding PP1 0.699
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ up-regulates img/direct-activation.png binding GYS1 0.71
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ up-regulates img/direct-activation.png binding GYS2 0.77
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PPP1R3B 0.414
Publications: 1 Organism: Homo Sapiens