| + |
AMPK | down-regulates activity 
phosphorylation
|
GYS2 |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263101 |
Ser8 |
MLRGRSLsVTSLGGL |
in vitro |
|
| pmid |
sentence |
| 22233421 |
Recombinant muscle GYS1 (glycogen synthase 1) and recombinant liver GYS2 were phosphorylated by recombinant AMPK (AMP-activated protein kinase) in a time-dependent manner and to a similar stoichiometry. The phosphorylation site in GYS2 was identified as Ser7, which lies in a favourable consensus for phosphorylation by AMPK. Phosphorylation of GYS1 or GYS2 by AMPK led to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6-P (glucose-6-phosphate)] and Glc-6-P (assayed at low UDP-Glc concentrations). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
GYS2 | up-regulates quantity 
chemical modification
|
α-D-glucosyl-glycogenin |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267939 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26882899 |
Glycogenin initiates the first step of glycogen synthesis by self glycosylation of a short 8–12 glucose oligosaccharide primer. Glycogen synthase (GYS) elongates the glucose oligossacharide primer, which utilises UDP-glucose as the glucosyl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis |
| + |
PPP1R3C | up-regulates
binding
|
GYS2 |
0.741 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271731 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 36551183 |
In the liver, PTG and PPP1R3B(GL)are expressed at roughly equivalent levels [55], and they jointly promote hepatic glycogen mobilization and storage. PTG overexpression significantly increased glycogen content, mainly due to its ability to promote the redistribution of PP1 and glycogen synthase to glycogen granules, significantly increasing GS activity and glycogen synthesis (Figure 2) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
GYS2 | down-regulates quantity
chemical modification
|
UDP-alpha-D-glucose(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267937 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26882899 |
Glycogenin initiates the first step of glycogen synthesis by self glycosylation of a short 8–12 glucose oligosaccharide primer. Glycogen synthase (GYS) elongates the glucose oligossacharide primer, which utilises UDP-glucose as the glucosyl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis |
| + |
PPP1R3B | up-regulates
binding
|
GYS2 |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271732 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 36551183 |
In the liver, PTG and PPP1R3B(GL)are expressed at roughly equivalent levels [55], and they jointly promote hepatic glycogen mobilization and storage. PTG overexpression significantly increased glycogen content, mainly due to its ability to promote the redistribution of PP1 and glycogen synthase to glycogen granules, significantly increasing GS activity and glycogen synthesis (Figure 2) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
3.0
GYS2
- 
- 