+ |
Ub:E2 | up-regulates activity
ubiquitination
|
IRF2BP1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271057 |
|
|
Homo sapiens |
|
pmid |
sentence |
34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
IRF2BP1 | up-regulates activity
binding
|
IRF2 |
0.715 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-224045 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
12799427 |
We have identified two novel proteins that interact specifically with the C-terminal repression domain of Interferon Regulatory Factor-2 (IRF-2). These proteins, which we term IRF-2 binding proteins 1 and 2 (IRF-2BP1 and IRF-2BP2, the latter having two splicing isoforms, A and B), are nuclear proteins, and have the properties of IRF-2-dependent transcriptional co-repressors that can inhibit both enhancer-activated and basal transcription in a manner that is not dependent upon histone deacetylation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |