| + |
IRF2 | up-regulates quantity by expression 
transcriptional regulation
|
CIITA |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271681 |
|
|
|
|
| pmid |
sentence |
| 11464288 |
In addition to IRF-1, IRF-2, another member of the IRF family, also activates the human CIITA type IV promoter, and IRF-2 cooperates with IRF-1 to activate the promoter in transient transfection assays. |
|
| Publications: |
1 |
| + |
IRF2 | up-regulates quantity by expression 
transcriptional regulation
|
TAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254530 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15778351 |
We also show that this cytokine-dependent expression of TAP1 transcripts depends on STAT1 and IFN regulatory factor-2 (IRF-2), but not on IRF-1, and provide evidence that IRF-2 constitutively binds to the TAP1 gene promoter and enhances TAP1 promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF2BP2 | up-regulates activity
binding
|
IRF2 |
0.652 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-224073 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12799427 |
We have identified two novel proteins that interact specifically with the C-terminal repression domain of Interferon Regulatory Factor-2 (IRF-2). These proteins, which we term IRF-2 binding proteins 1 and 2 (IRF-2BP1 and IRF-2BP2, the latter having two splicing isoforms, A and B), are nuclear proteins, and have the properties of IRF-2-dependent transcriptional co-repressors that can inhibit both enhancer-activated and basal transcription in a manner that is not dependent upon histone deacetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF2 | down-regulates quantity by repression 
transcriptional regulation
|
DST |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254493 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15560761 |
Transient transfection studies with BPAG1 promoter-luciferase reporter gene plasmids and IRF1 and IRF2 expression plasmids revealed that IRF1 and IRF2 directly down-regulated BPAG1 gene transcription in cultured normal human epidermal keratinocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates activity
binding
|
IRF2 |
0.564 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254532 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15778351 |
We show that IRF-2 forms a complex with STAT1 and the cytokine-responsive region of the TAP1 promoter in any TPO or IFN-gamma target cells tested. Interaction of IRF-2 and STAT1 on the promoter depends on the DNA-binding domain of IRF-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF2BP1 | up-regulates activity
binding
|
IRF2 |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-224045 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12799427 |
We have identified two novel proteins that interact specifically with the C-terminal repression domain of Interferon Regulatory Factor-2 (IRF-2). These proteins, which we term IRF-2 binding proteins 1 and 2 (IRF-2BP1 and IRF-2BP2, the latter having two splicing isoforms, A and B), are nuclear proteins, and have the properties of IRF-2-dependent transcriptional co-repressors that can inhibit both enhancer-activated and basal transcription in a manner that is not dependent upon histone deacetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IRF2
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