Relation Results

Summary

Name BRSK2
Full Name Serine/threonine-protein kinase BRSK2
Synonyms Brain-selective kinase 2, 2.7.11.26, Brain-specific serine/threonine-protein kinase 2, BR serine/threonine-protein kinase 2, Serine/threonine-protein kinase 29, Serine/threonine-protein kinase SAD-A | C11orf7, PEN11B, SADA, STK29
Primary ID Q8IWQ3
Links - -
Type protein
Relations 4
Function Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphor ...
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Type: Score: Layout: SPV 
0.4810.2950.20.25STK11BRSK2PRKAA1PKAWDR45

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ STK11up-regulates img/direct-activation.png phosphorylation BRSK2 0.481
Identifier Residue Sequence Organism Cell Line
SIGNOR-122485 Thr174 VGDSLLEtSCGSPHY Homo sapiens
pmid sentence
Lkb1 is a master kinase that activates 13 kinases of the ampk subfamily, including mark/par-1we recently demonstrated that the lkb1 tumour suppressor kinase, in complex with the pseudokinase strad and the scaffolding protein mo25, phosphorylates and activates amp-activated protein kinase (ampk). A total of 12 human kinases (nuak1, nuak2, brsk1, brsk2, qik, qsk, sik, mark1, mark2, mark3, mark4 and melk) are related to ampk. Here we demonstrate that lkb1 can phosphorylate the t-loop of all the members of this subfamily, apart from melk, increasing their activity >50-fold
Publications: 1 Organism: Homo Sapiens
+ BRSK2up-regulates img/direct-activation.png phosphorylation PRKAA1 0.295
Identifier Residue Sequence Organism Cell Line
SIGNOR-176594 Thr183 SDGEFLRtSCGSPNY Homo sapiens
pmid sentence
Ampka1 activators increased phosphorylation level and cytoplasmic localization (reduced nuclear/cytoplasmic ratio). Ampka1 activators reduced rna synthesis in the nucleoli.
Publications: 1 Organism: Homo Sapiens
+ PKAup-regulates activity img/direct-activation.png phosphorylation BRSK2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276056 Thr260 VDAARRLtLEHIQKH in vitro
pmid sentence
BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260
Publications: 1 Organism: In Vitro
+ BRSK2up-regulates activity img/direct-activation.png phosphorylation WDR45 0.25
Identifier Residue Sequence Organism Cell Line
SIGNOR-268482 Homo sapiens U2-OS Cell
pmid sentence
WIPI4 is stimulated by AMPK, NUAK2 and BRSK2. This finding is supported by the results of our kinome screening, which identified AMPK and the AMKP-related kinases NUAK2 and BRSK2, all of which function downstream of LKB1 (ref. 69) and stimulate the localization of WIPI4 to nascent autophagosomes.
Publications: 1 Organism: Homo Sapiens
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