Summary

Name BRSK2
Full Name Serine/threonine-protein kinase BRSK2
Synonyms Brain-selective kinase 2, 2.7.11.26, Brain-specific serine/threonine-protein kinase 2, BR serine/threonine-protein kinase 2, Serine/threonine-protein kinase 29, Serine/threonine-protein kinase SAD-A | C11orf7, PEN11B, SADA, STK29
Primary ID Q8IWQ3
Links - -
Type protein
Relations 4
Function Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ STK11up-regulates img/direct-activation.png phosphorylation BRSK2 0.481
Publications: 1 Organism: Homo Sapiens
+ BRSK2up-regulates img/direct-activation.png phosphorylation PRKAA1 0.294
Publications: 1 Organism: Homo Sapiens
+ PKAup-regulates activity img/direct-activation.png phosphorylation BRSK2 0.2
Publications: 1 Organism: In Vitro
+ BRSK2up-regulates activity img/direct-activation.png phosphorylation WDR45 0.25
Publications: 1 Organism: Homo Sapiens