Summary

Name WDR45
Full Name WD repeat domain phosphoinositide-interacting protein 4
Synonyms WIPI-4, WD repeat-containing protein 45 | WDRX1, WDRXI4, WIPI4
Primary ID Q9Y484
Links - -
Type protein
Relations 6
Function Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066).

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Relations

Regulator Mechanism target score ℹ
+ PIP3up-regulates activity img/direct-activation.png chemical activation WDR45 0.8
Publications: 1 Organism: Homo Sapiens
+ WDR45up-regulates activity img/direct-activation.png binding ATG2B 0.668
Publications: 1 Organism: Homo Sapiens
+ AMPKup-regulates activity img/direct-activation.png phosphorylation WDR45 0.318
Publications: 1 Organism: Homo Sapiens
+ WDR45up-regulates activity img/direct-activation.png binding ATG2A 0.538
Publications: 1 Organism: Homo Sapiens
+ BRSK2up-regulates activity img/direct-activation.png phosphorylation WDR45 0.25
Publications: 1 Organism: Homo Sapiens
+ NUAK2up-regulates activity img/direct-activation.png phosphorylation WDR45 0.265
Publications: 1 Organism: Homo Sapiens