+ |
CDK5 | up-regulates
phosphorylation
|
LMTK2 |
0.509 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-195329 |
Ser1450 |
LQTSKYFsPPPPARS |
Homo sapiens |
Neuron |
pmid |
sentence |
22220831 |
Here, we demonstrate that lmtk2 is phosphorylated on serine-1418 (lmtk2ser ) by cdk5/p35 and present evidence that this regulates its ability to phosphorylate pp1cthr __ |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Brain |
+ |
LMTK2 | down-regulates activity
phosphorylation
|
CFTR |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278227 |
Ser737 |
EPLERRLsLVPDSEQ |
Homo sapiens |
|
pmid |
sentence |
24727471 |
The present study discovered that in human airway epithelial cells CFTR endocytosis is regulated by the LMTK2-mediated phosphorylation of CFTR-Ser737 that decreases the cell surface density of CFTR Cl\u2212 channels and inhibits CFTR-mediated Cl\u2212 secretion.|Together, the above results demonstrate that the LMTK2 phosphorylation of CFTR-Ser737 facilitates CFTR endocytosis and reduces the plasma membrane abundance of CFTR in human airway epithelial cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LMTK2 | down-regulates activity
phosphorylation
|
PPP1CA |
0.586 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-94631 |
Thr320 |
NPGGRPItPPRNSAK |
Homo sapiens |
|
pmid |
sentence |
12393858 |
Kpi-2 kinase domain phosphorylated protein phosphatase-1 (pp1c) at thr(320), which attenuated pp1c activity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CDK5 | down-regulates
phosphorylation
|
LMTK2 |
0.509 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-102717 |
|
|
Homo sapiens |
|
pmid |
sentence |
12832520 |
Cprk displays catalytic activity in in vitro kinase assays and is itself phosphorylated by cdk5/p35. Cdk5/p35 inhibits cprk activity. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-102652 |
|
|
Homo sapiens |
|
pmid |
sentence |
12832520 |
Cprk displays catalytic activity in in vitro kinase assays and is itself phosphorylated by cdk5/p35. Cdk5/p35 inhibits cprk activity. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |