| + |
PRKACA | up-regulates 
phosphorylation
|
TPH2 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178018 |
Ser19 |
YWARRGFsLDSAVPE |
Homo sapiens |
|
| pmid |
sentence |
| 18339632 |
We also demonstrate that phosphorylation of serine 19, a protein kinase a consensus site located in this n-terminal domain, results in increased tph2 stability and consequent increases in enzyme output in cell culture systems |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TPH2 | up-regulates quantity
chemical modification
|
5-hydroxy-L-tryptophan |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264012 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31024440 |
In serotonergic neurons Trp serves as the precursor for 5-HT. The 5-HT metabolic pathway is initiated by Trp being hydroxylated to the intermediate 5-hydroxytryptophan (5-HTP), which is subsequently decarboxylated to become 5-HT|Thus, the rate limiting step in the biosynthesis of 5-HT is the hydroxylation of Trp which is catalyzed by the enzyme tryptophan hydroxylase (TPH) (Figure 1). This enzyme is specific for 5-HT producing cells, however, it is present in two different isoforms, TPH1 and TPH2 [reviewed in (22, 23)]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TPH2 | down-regulates quantity 
chemical modification
|
tryptophan |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264011 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31024440 |
In serotonergic neurons Trp serves as the precursor for 5-HT. The 5-HT metabolic pathway is initiated by Trp being hydroxylated to the intermediate 5-hydroxytryptophan (5-HTP), which is subsequently decarboxylated to become 5-HT|Thus, the rate limiting step in the biosynthesis of 5-HT is the hydroxylation of Trp which is catalyzed by the enzyme tryptophan hydroxylase (TPH) (Figure 1). This enzyme is specific for 5-HT producing cells, however, it is present in two different isoforms, TPH1 and TPH2 [reviewed in (22, 23)]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TPH2
- 
- 