3.0
Summary
| Name |  SKA3View Modifications |
| Full Name | Spindle and kinetochore-associated protein 3 |
| Synonyms | SKA3_HUMAN | C13orf3, RAMA1 |
| Primary ID | Q8IX90 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AURKB | up-regulates activity 
phosphorylation
|
SKA3 | 0.464 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CDK1 | up-regulates activity
phosphorylation
|
SKA3 | |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | SKA3 | form complex 
binding
|
SKA complex | 0.917 |
| Publications: | 1 | Organism: | In Vitro | |