| + |
PINK1 | down-regulates quantity by destabilization
phosphorylation
|
RHOT1 |
0.777 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273723 |
Ser156 |
AKNLKNIsELFYYAQ |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22078885 |
PINK1 phosphorylates Miro, a component of the primary motor/adaptor complex that anchors kinesin to the mitochondrial surface. The phosphorylation of Miro activates proteasomal degradation of Miro in a Parkin-dependent manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279549 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28973175 |
PINK1 also phosphorylates Miro1 which targets Miro1 for degradation in a Parkin dependent manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272728 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22078885 |
PINK1 phosphorylates Miro, a component of the primary motor/adaptor complex that anchors kinesin to the mitochondrial surface. The phosphorylation of Miro activates proteasomal degradation of Miro in a Parkin-dependent manner. in Miro1, Ser156 (homologous to Ser182 in Drosophila) and Thr298, 299 (homologous to Ser324, 325 in Drosophila, Figure 6C). |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PRKN | down-regulates quantity by destabilization
ubiquitination
|
RHOT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278561 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24647965 |
We observe that Parkin efficiently ubiquitylates Miro1 at highly conserved lysine residues, 153, 230, 235, 330 and 572, upon phosphorylation by PINK1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |