+ |
PINK1 | down-regulates quantity by destabilization
phosphorylation
|
RHOT1 |
0.773 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273723 |
Ser156 |
AKNLKNIsELFYYAQ |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
22078885 |
PINK1 phosphorylates Miro, a component of the primary motor/adaptor complex that anchors kinesin to the mitochondrial surface. The phosphorylation of Miro activates proteasomal degradation of Miro in a Parkin-dependent manner. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272728 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
22078885 |
PINK1 phosphorylates Miro, a component of the primary motor/adaptor complex that anchors kinesin to the mitochondrial surface. The phosphorylation of Miro activates proteasomal degradation of Miro in a Parkin-dependent manner. in Miro1, Ser156 (homologous to Ser182 in Drosophila) and Thr298, 299 (homologous to Ser324, 325 in Drosophila, Figure 6C). |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
PRKN | down-regulates quantity by destabilization
ubiquitination
|
RHOT1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278561 |
|
|
Homo sapiens |
|
pmid |
sentence |
24647965 |
We observe that Parkin efficiently ubiquitylates Miro1 at highly conserved lysine residues, 153, 230, 235, 330 and 572, upon phosphorylation by PINK1. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |