Relation Results

Summary

Name CACNA2D3
Full Name Voltage-dependent calcium channel subunit alpha-2/delta-3
Synonyms Voltage-gated calcium channel subunit alpha-2/delta-3 |
Primary ID Q8IZS8
Links - -
Type protein
Relations 5
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium ...
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Type: Score: Layout: SPV 
0.80.70.80.70.2CACNA2D3calcium(2+)ApoptosisprogesteroneProliferationp38

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Relations
Regulator
Mechanism
target
score ℹ
+ CACNA2D3up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266853 Homo sapiens
pmid sentence
Our findings showed that increased intracellular calcium (Ca2+ ) mediated by overexpression of CACNA2D3 induced mitochondrial-mediated apoptosis, upregulation of NLK (through the Wnt/Ca2+ pathway) and inhibition of the epithelial-to-mesenchymal transition.
Publications: 1 Organism: Homo Sapiens
+ CACNA2D3up-regulates img/indirect-activation.png Apoptosis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-266855 Homo sapiens
pmid sentence
Overexpression of CACNA2D3 reduced proliferation and migration, but increased apoptosis and Ca2+ influx in Ishikawa and RL95-2 cells.
Publications: 1 Organism: Homo Sapiens
+ progesteroneup-regulates quantity img/indirect-activation.png CACNA2D3 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266856 Homo sapiens
pmid sentence
In vivo and in vitro, the addition of P4 upregulated the expression of CACNA2D3 and silencing of CACNA2D3 impaired the function of P4 on cell apoptosis and proliferation.
Publications: 1 Organism: Homo Sapiens
+ CACNA2D3down-regulates img/indirect_inhibition.png Proliferation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-266854 Homo sapiens
pmid sentence
Overexpression of CACNA2D3 reduced proliferation and migration, but increased apoptosis and Ca2+ influx in Ishikawa and RL95-2 cells.
Publications: 1 Organism: Homo Sapiens
+ CACNA2D3up-regulates activity img/indirect-activation.png p38 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266857 Homo sapiens
pmid sentence
The results indicated that the overexpression of CACNA2D3 induced an increase in intracellular Ca2+ and increased the levels of p-p38 MAPK. These data indicated that the p38 MAPK pathway is activated by overexpression of CACNA2D3 and P4 induction.
Publications: 1 Organism: Homo Sapiens
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