| + |
p38 | down-regulates quantity by destabilization 
phosphorylation
|
CDC25B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276350 |
Ser101 |
ASESSLSsESSESSD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21807946 |
Recently, we showed that Cdc25B is degraded rapidly by non-genotoxic stimuli that activate stress-responsive MAPKs, such as Jun N-terminal kinase (JNK) and p38 (Uchida et al., 2009). Our results suggested that these kinases phosphorylate specific Ser residues in the N-terminal region (S101 and S103) to induce Cdc25B degradation.Here, we report that Cdc25B was ubiquitylated by SCF(βTrCP) E3 ligase upon phosphorylation at two Ser residues in the βTrCP-binding-motif-like sequence D(94)AGLCMDSPSP(104). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276349 |
Ser103 |
ESSLSSEsSESSDAG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21807946 |
Recently, we showed that Cdc25B is degraded rapidly by non-genotoxic stimuli that activate stress-responsive MAPKs, such as Jun N-terminal kinase (JNK) and p38 (Uchida et al., 2009). Our results suggested that these kinases phosphorylate specific Ser residues in the N-terminal region (S101 and S103) to induce Cdc25B degradation.Here, we report that Cdc25B was ubiquitylated by SCF(βTrCP) E3 ligase upon phosphorylation at two Ser residues in the βTrCP-binding-motif-like sequence D(94)AGLCMDSPSP(104). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
p38 | up-regulates activity 
phosphorylation
|
KRT20 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263070 |
Ser13 |
RSFHRSLsSSLQAPV |
in vitro |
|
| pmid |
sentence |
| 20724476 |
P38 phosphorylates the type II keratin, K8 at Ser73, whereas MK2 phosphorylates the binding partners K18 at Ser52 and K20 at Ser13. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
p38 | up-regulates
phosphorylation
|
HNF4A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143046 |
Ser167 |
VLSRQITsPVSGING |
Homo sapiens |
|
| pmid |
sentence |
| 16351573 |
Our results indicate that p38 kinase-mediated ser158 phosphorylation is essential for augmentation of the dna binding and transactivation potential of hnf4alpha |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
p38 | down-regulates
phosphorylation
|
NFATC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87393 |
Ser168 |
QGGGAFFsPSPGSSS |
Homo sapiens |
|
| pmid |
sentence |
| 11997522 |
Phosphorylation of nfatc4 by p38 mitogen-activated protein kinasesthe p38 map kinase phosphorylates multiple residues, including ser(168) and ser(170), in the nfat homology domain of nfatc4. Replacement of ser(168,170) with ala promotes nuclear localization of nfatc4 and increases nfat-mediated transcription activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87397 |
Ser170 |
GGAFFSPsPGSSSLS |
Homo sapiens |
|
| pmid |
sentence |
| 11997522 |
Phosphorylation of nfatc4 by p38 mitogen-activated protein kinasesthe p38 map kinase phosphorylates multiple residues, including ser(168) and ser(170), in the nfat homology domain of nfatc4. Replacement of ser(168,170) with ala promotes nuclear localization of nfatc4 and increases nfat-mediated transcription activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
p38 | down-regulates activity
phosphorylation
|
CDC25C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107420 |
Ser216 |
SGLYRSPsMPENLNR |
Homo sapiens |
|
| pmid |
sentence |
| 11333986 |
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteins phosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
p38 | up-regulates quantity by stabilization
phosphorylation
|
FOXC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275914 |
Ser241 |
PSPPQPLsPAAALGS |
|
|
| pmid |
sentence |
| 31650548 |
P38 interacts with and phosphorylates the Ser241 and ser272 sites of FOXC1 to maintain its stability by inhibiting ubiquitination and degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275912 |
Ser272 |
SSLSSGSsPPGSLPS |
|
|
| pmid |
sentence |
| 31650548 |
P38 interacts with and phosphorylates the Ser241 and ser272 sites of FOXC1 to maintain its stability by inhibiting ubiquitination and degradation. |
|
| Publications: |
2 |
| + |
p38 | down-regulates activity
phosphorylation
|
DROSHA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264847 |
Ser300 |
RHRDNRRsPSLERSY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25699712 |
Our findings suggest that phosphorylation of Drosha at multiple sites including S300 promotes its translocation to the cytoplasm. Interestingly, GSK3beta can phosphorylate Drosha at S300 and S302 in vitro. This has been reported to promote the nuclear localization of Drosha under basal condition (Tang et al., 2011). Thus, it appears that phosphorylation of S300 by GSK3beta and p38 MAPK is involved in opposing processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
p38 | down-regulates activity
phosphorylation
|
CDC25B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107412 |
Ser323 |
QRLFRSPsMPCSVIR |
Homo sapiens |
|
| pmid |
sentence |
| 11333986 |
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteins phosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107416 |
Ser375 |
ARVLRSKsLCHDEIE |
Homo sapiens |
|
| pmid |
sentence |
| 11333986 |
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteins phosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
p38 | up-regulates quantity by stabilization
phosphorylation
|
CDT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276362 |
Ser391 |
LRSAAPSsPGSPRPA |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21930785 |
We discovered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G(1) phase, is a substrate of the stress-activated mitogen-activated protein (MAP) kinases p38 and c-Jun N-terminal kinase (JNK). These MAP kinases phosphorylate Cdt1 both during unperturbed G(2) phase and during an acute stress response. Phosphorylation renders Cdt1 resistant to ubiquitin-mediated degradation during S phase and after DNA damage by blocking Cdt1 binding to the Cul4 adaptor, Cdt2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276363 |
Ser491 |
GSCCTIMsPGEMEKH |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21930785 |
We discovered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G(1) phase, is a substrate of the stress-activated mitogen-activated protein (MAP) kinases p38 and c-Jun N-terminal kinase (JNK). These MAP kinases phosphorylate Cdt1 both during unperturbed G(2) phase and during an acute stress response. Phosphorylation renders Cdt1 resistant to ubiquitin-mediated degradation during S phase and after DNA damage by blocking Cdt1 binding to the Cul4 adaptor, Cdt2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
p38 | down-regulates quantity by destabilization
phosphorylation
|
BCL2L11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260443 |
Ser69 |
GPLAPPAsPGPFATR |
Rattus norvegicus |
|
| pmid |
sentence |
| 15486195 |
Ser69 can also be phosphorylated by JNK and p38MAPK at least in vitro. Phosphorylation of BimEL on Ser69 promotes its ubiquitination. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS |
| + |
p38 | down-regulates activity
phosphorylation
|
BCL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260450 |
Ser87 |
AAAGPALsPVPPVVH |
Homo sapiens |
|
| pmid |
sentence |
| 19336399 |
The protein's reduced antiapoptotic capacity was related to phosphorylation of its threonine 56 and serine 87 residues by virally activated p38mapk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION |
| + |
p38 | down-regulates activity
phosphorylation
|
TP53BP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264445 |
Thr1609 |
LGPYEAVtPLTKAAD |
in vitro |
|
| pmid |
sentence |
| 24703952 |
Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR) motif.|Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks |phosphorylation of T1609 is likely to be mediated by p38 MAPK |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
p38 | down-regulates
phosphorylation
|
MAPT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171062 |
Thr548 |
KKVAVVRtPPKSPSS |
Homo sapiens |
|
| pmid |
sentence |
| 21215781 |
However, other kinases, such as cdk5, p38 and pka, also phosphorylate tau at t231tau phosphorylation at t231, s235 and s262 also contributes to the dissociation of tau from microtubules |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
p38 | up-regulates activity
phosphorylation
|
FH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266316 |
Thr90 |
GVTERMPtPVIKAFG |
Homo sapiens |
Non-small Cell Lung Cancer Cell |
| pmid |
sentence |
| 30683654 |
In this study, we found that TGFβ induces FH Thr 90 phosphorylation by p38. Upon Notch activation, nuclear NICD promotes the interaction between CSL and p38-phosphorylated FH and thus FH/CSL/p53/Smad complex formation; this facilitates FH recruitment to p53-targed p21 promoter, where FH inhibits KDM2A-mediated demethylation of H3K36me2 through local production of fumarate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
p38 | up-regulates
phosphorylation
|
KRT8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270125 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11788583 |
Keratin 8 (k8) serine 73 occurs within a relatively conserved type ii keratin motif . Here we show that ser-73 is exclusively phosphorylated in vitro by p38 mitogen-activated protein kinase. The ser-73 --> ala-associated filament reorganization defect is rescued by a ser-73 --> asp mutation. Also, disease-causing keratin mutations can modulate keratin phosphorylation and organization, which may affect disease pathogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
p38 | down-regulates activity
phosphorylation
|
EEF2K |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270127 |
|
|
in vitro |
|
| pmid |
sentence |
| 12171600 |
Inhibition of eEF2 kinase resulting from phosphorylation of Ser-396 by SAPK2a p38 was approx.25%. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAP2K6 | up-regulates activity
|
p38 |
0.733 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260720 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10480932 |
P38 mitogen-activated protein kinase, and its direct activator MKK6 are rapidly activated in response to TGF-beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260721 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 9430721 |
The p38 MAP kinase kinase MKK6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma MAP kinase isoforms |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
TNFRSF17 | up-regulates 
|
p38 |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269917 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10903733 |
Overexpression of bcma activates the p38 mapk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAB2 | up-regulates
binding
|
p38 |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205446 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25290089 |
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM27 | up-regulates
|
p38 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269915 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
We found rfp-mediated activation of both exogenous and endogenous forms of the other stress-activated mapk, p38. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
CACNA2D3 | up-regulates activity
|
p38 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266857 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31746409 |
The results indicated that the overexpression of CACNA2D3 induced an increase in intracellular Ca2+ and increased the levels of p-p38 MAPK. These data indicated that the p38 MAPK pathway is activated by overexpression of CACNA2D3 and P4 induction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
p38 | up-regulates
|
Actin_cytoskeleton_reorganization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254360 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11591790 |
The p21 G protein Rho and its targets, Rho-associated coiled-coil forming protein kinases (p160ROCK/ROCK I/ROKβ and Rho kinase/ROCK II/ROKα), play a crucial role in actin cytoskeleton reorganization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR4 | up-regulates activity
phosphorylation
|
p38 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261928 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28137827 |
Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the activation of c-Jun, CREB, and NF-κB. Activation of neutrophils by S100A9 also proceeds via p38 MAPK, JNK, and ERK1/2 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K3 | up-regulates activity
phosphorylation
|
p38 |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260723 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 7839144 |
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
MAP2K4 | up-regulates activity
phosphorylation
|
p38 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260722 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 7839144 |
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
CCR3 | up-regulates activity
|
p38 |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256092 |
|
|
Homo sapiens |
Eosinophil |
| pmid |
sentence |
| 10706854 |
Activation of ERK2 and p38 by eotaxin is mediated through CCR3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(-)-anisomycin | up-regulates
chemical activation
|
p38 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269916 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
p38 | up-regulates
phosphorylation
|
ATF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270124 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10085140 |
Our results indicate that atf-2 not only directly binds to smad3/4 hetero-oligomers but also that atf-2 is phosphorylated by tgf-beta signaling via tak1 and p38. The two pathways, smad and tak1, synergistically enhance the activity of atf-2 which acts as their common nuclear target |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
p38 | up-regulates
phosphorylation
|
TP53 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270126 |
|
|
Homo sapiens |
Skin Cancer Cell |
| pmid |
sentence |
| 17254968 |
We show that prak activates p53 by direct phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
N | up-regulates activity
|
p38 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261132 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 15294014 |
Furthermore, N expression up-regulated the activity of stress-activated protein kinases, namely the JNK and p38 MAPK pathways. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION |
| + |
3a | up-regulates activity
|
p38 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260193 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 18632968 |
Severe Acute Respiratory Syndrome Coronavirus 3a Protein Activates the Mitochondrial Death Pathway Through p38 MAP Kinase Activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION |
| + |
7a | up-regulates activity
|
p38 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260754 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16378980 |
While there is a low level of activated p38 normally found in 293T cells, expression of 7a-protein stimulated larger amounts of activated p38 during the 24-h time course. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION |
| + |
SDCBP | up-regulates activity
|
p38 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260753 |
|
|
Chlorocebus aethiops |
Vero Cell |
| pmid |
sentence |
| 25122212 |
Overall, these results support the hypothesis that the interaction of E protein PBM with syntenin facilitates the recruitment of syntenin in the cytosol and leads to p38 MAPK activation. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
E | up-regulates activity
|
p38 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260751 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25122212 |
Interestingly, an increase in p38 MAPK activation was observed during infection with viruses containing E protein PBM, similarly to what was observed in the lungs of SARS-CoV-infected mice. These results indicated that the E protein PBM is involved in p38 MAPK activation in response to SARS-CoV infection. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Lung |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION |
| + |
DLG1 | up-regulates activity
binding
|
p38 |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274143 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17187070 |
Dlgh1 immunoprecipitates were specifically enriched for activated p38 phosphorylated at Thr180 and Tyr182; phosphorylated p38 was not detected in the unbound fraction from stimulated samples |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAB3 | up-regulates
binding
|
p38 |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205452 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25290089 |
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MFGE8 | down-regulates activity 
|
p38 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260651 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 19020771 |
In our current study, we have shown that after LPS-stimulation, MFG-E8-mediated apoptotic cell phagocytosis suppresses various ERK1/2, p38, JNK, and NFκB activation, resulting in a lower TNF-α release. We also explored whether MFG-E8 helps to suppress the proinflammatory pathway within RPMs. We hence incubated the macrophages with apoptotic cells and stimulated them with LPS and examined the activation of MAP kinase and NFkB pathways after the exogenous addition of recombinant MFG-E8 (rMFG-E8). While apoptotic cells alone had no effect on these pathways, the addition of rMFG-E8 to apoptotic cells prior to phagocytosis and LPS stimulation had a marked suppressive effect on all of the investigated pathways, particularly on the p38 and NFκB pathways that play a key role in the cytokine response of macrophages |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
p38 | up-regulates activity
phosphorylation
|
DDIT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260724 |
|
|
in vitro |
|
| pmid |
sentence |
| 8650547 |
Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
TAB1 | up-regulates
binding
|
p38 |
0.821 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205440 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25290089 |
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR3 | up-regulates
|
p38 |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254358 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11591790 |
We and others have recently found that eotaxin activates extracellular signal-regulated kinase (ERK)-1/2 and p38 mitogen-activated protein (MAP) kinases in eosinophils, and that these kinases are indispensable for eosinophil chemotaxis and degranulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
p38