| + |
ITCH | up-regulates activity 
binding
|
SPART |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261308 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20719964 |
SPG20 Protein Spartin Is Recruited to Midbodies by ESCRT-III Protein Ist1 and Participates in Cytokinesis. Spartin colocalizes with Ist1 at the midbody, and depletion of Ist1 in cells significantly decreases the number of cells where spartin is present at midbodies. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPART | up-regulates activity
binding
|
WWP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261307 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19580544 |
Cytosolic endogenous spartin is mono-ubiquitinated and we demonstrate that it interacts via a PPXY motif with the ubiquitin E3 ligases AIP4 [atrophin-interacting protein 4; ITCH (itchy E3 ubiquitin protein ligase homologue] [corrected] and AIP5 (WWP1). Surprisingly, the PPXY motif, AIP4 and AIP5 are not required for spartin's ubiquitination, and so we propose that spartin acts as an adaptor for these proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPART | up-regulates activity
binding
|
ITCH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261306 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19580544 |
Cytosolic endogenous spartin is mono-ubiquitinated and we demonstrate that it interacts via a PPXY motif with the ubiquitin E3 ligases AIP4 [atrophin-interacting protein 4; ITCH (itchy E3 ubiquitin protein ligase homologue] [corrected] and AIP5 (WWP1). Surprisingly, the PPXY motif, AIP4 and AIP5 are not required for spartin's ubiquitination, and so we propose that spartin acts as an adaptor for these proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SPART
- 
- 