3.0
Summary
| Name |  TTC5View Modifications |
| Full Name | Tetratricopeptide repeat protein 5 |
| Synonyms | TPR repeat protein 5, Stress-responsive activator of p300, Strap | |
| Primary ID | Q8N0Z6 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM | up-regulates activity 
phosphorylation
|
TTC5 | 0.517 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TTC5 | up-regulates activity
binding
|
JMY | 0.51 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TTC5 | up-regulates activity
binding
|
EP300 | 0.54 |
| Publications: | 1 | Organism: | Homo Sapiens | |