Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-274125 |
|
|
Homo sapiens |
Glioma Stem Cell |
pmid |
sentence |
27923907 |
In this study, we demonstrate that the deubiquitinase USP13 stabilizes c-Myc by antagonizing FBXL14-mediated ubiquitination to maintain GSC self-renewal and tumorigenic potential. USP13 was preferentially expressed in GSCs, and its depletion potently inhibited GSC proliferation and tumor growth by promoting c-Myc ubiquitination and degradation. |
|