Relation Results

Summary

Name UNC80
Full Name Protein unc-80 homolog
Synonyms UNC80_HUMAN | C2orf21, KIAA1843
Primary ID Q8N2C7
Links - -
Type protein
Relations 4
Function Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance ...
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Type: Score: Layout: SPV 
0.810.8030.353UNC80NALCNUNC79SRC

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Relations
Regulator
Mechanism
target
score ℹ
+ UNC80up-regulates activity img/direct-activation.png binding NALCN 0.81
Identifier Residue Sequence Organism Cell Line
SIGNOR-265184 Homo sapiens Brain
pmid sentence
The NALCN complex in the brain consists of NALCN, UNC80 and UNC79. UNC80 directly associates with NALCN and UNC79 forms part of the complex by its interaction with UNC80.
Identifier Residue Sequence Organism Cell Line
SIGNOR-265180 Homo sapiens HEK-293 Cell
pmid sentence
UNC80 is a protein that is associated with the NALCN Na(+) leak cation channel, and is required for the activation of this channel by the neuropeptide substance P through GPCRs in a G-protein-independent fashion. Here, we show that UNC80 binds Src kinases and recruits Src into the channel complex. 
Publications: 2 Organism: Homo Sapiens
+ UNC80up-regulates activity img/direct-activation.png binding UNC79 0.803
Identifier Residue Sequence Organism Cell Line
SIGNOR-265183 Homo sapiens Brain
pmid sentence
The NALCN complex in the brain consists of NALCN, UNC80 and UNC79. UNC80 directly associates with NALCN and UNC79 forms part of the complex by its interaction with UNC80.
Publications: 1 Organism: Homo Sapiens
+ UNC80up-regulates activity img/direct-activation.png binding SRC 0.353
Identifier Residue Sequence Organism Cell Line
SIGNOR-265179 Homo sapiens HEK-293 Cell
pmid sentence
UNC80 is a protein that is associated with the NALCN Na(+) leak cation channel, and is required for the activation of this channel by the neuropeptide substance P through GPCRs in a G-protein-independent fashion. Here, we show that UNC80 binds Src kinases and recruits Src into the channel complex. 
Publications: 1 Organism: Homo Sapiens
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