| + |
AMPK | up-regulates activity 
phosphorylation
|
ARMC10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266413 |
Ser45 |
LGIRSSKsAGALEEG |
Homo sapiens |
|
| pmid |
sentence |
| 30631047 |
We validated one uncharacterized protein, ARMC10, and demonstrated that the S45 site of ARMC10 can be phosphorylated by AMPK both in vitro and in vivo. Moreover, ARMC10 overexpression was sufficient to promote mitochondrial fission, whereas ARMC10 knockout prevented AMPK-mediated mitochondrial fission. These results demonstrate that ARMC10 is an effector of AMPK that participates in dynamic regulation of mitochondrial fission and fusion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARMC10 | down-regulates activity 
binding
|
TP53 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266414 |
|
|
Homo sapiens |
SAOS-2 Cell, BEL-7404 Cell |
| pmid |
sentence |
| 17904127 |
Co-immunoprecipitation and GST pull-down assays have demonstrated that SVH-B directly interacts with p53. In both BEL-7404 cells and p53-null Saos-2 cells transfected with a temperature-sensitive mutant of p53, V143A, ectopically expressed SVH-B suppresses the transcriptional activity of p53, and suppression of SVH by RNA interference increases the transcriptional activity of p53. Our results suggested the function of SVH-B in accelerating growth and inhibition of apoptosis is related to its inhibitory binding to p53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ARMC10
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