3.0
Summary
| Name |  VPS8
|
| Full Name | Vacuolar protein sorting-associated protein 8 homolog |
| Synonyms | VPS8_HUMAN | KIAA0804 |
| Primary ID | Q8N3P4 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290). |
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ubiquitination
binding