+ |
Ub:E2 | up-regulates activity
ubiquitination
|
LNX2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271195 |
|
|
Homo sapiens |
|
pmid |
sentence |
34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LNX2 | down-regulates quantity by destabilization
polyubiquitination
|
NUMB |
0.625 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272423 |
|
|
in vitro |
|
pmid |
sentence |
26451611 |
Polyubiquitination of Human Numb by LNX2. The Zn-RING-Zn domain of LNX2 is a dimer and assumes a rigid elongated structure that undergoes autoubiquitination and undergoes N-terminal polyubiquitination. LNX2 can bind numb and induce its ubiquitination and subsequent proteasomal degradation |
|
Publications: |
1 |
Organism: |
In Vitro |