| + |
MINK1 | down-regulates activity 
phosphorylation
|
SMAD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276336 |
Thr322 |
SNVNRNStIENTRRH |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 21690388 |
Msn kinases directly phosphorylate α-helix 1 of Smad. we have identified Misshapen (Msn) and the mammalian orthologs TNIK, MINK1, and MAP4K4 as the kinases responsible for α-helix 1 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MINK1 | up-regulates activity 
phosphorylation
|
PRICKLE1 |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263095 |
Thr370 |
LSGNADDtLSRKLDD |
in vitro |
|
| pmid |
sentence |
| 22037766 |
We show that Mink1 phosphorylates Prickle on a conserved threonine residue and regulates its Rab5-dependent endosomal trafficking, a process required for the localized plasma membrane accumulation and function of Prickle. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
KRAS | up-regulates 
|
MINK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142985 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16337592 |
Mink is activated after ras induction via a mechanism involving reactive oxygen species and mediates stimulation of the stress-activated protein kinase p38 mapk downstream of the raf/erk pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNKSR1 | up-regulates quantity by stabilization
binding
|
MINK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282679 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
MINK1 | up-regulates
binding
|
KCNH2 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-49869 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9230439 |
Herg, a human homologue of the ether-a-go-go gene of the fruitfly drosophila melanogaster, encodes aproteinthat produces the rapidly activating cardiac delayed rectifier (i[kr]). / our results show that mink physically associates with herg and that the interaction leads to increased ikr current density. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNKSR3 | up-regulates quantity by stabilization
binding
|
MINK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282681 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
CNKSR2 | up-regulates quantity by stabilization
binding
|
MINK1 |
0.246 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282680 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
MINK1 | up-regulates activity
phosphorylation
|
NLRP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280042 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34480147 |
MINK1-mediated NLRP3 phosphorylation at Ser725 is critical for inflammasome activation.|These results suggest that MINK1 promotes NLRP3 inflammasome activation via direct interaction with NLRP3.|To determine whether MINK1 phosphorylated NLRP3 directly, we used Phos-tag SDS\u2013PAGE to detect the phosphorylation of NLRP3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
MINK1
- 
- 