Relation Results

Name	NGEF
Full Name	Ephexin-1
Synonyms	Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor \|
Primary ID	Q8N5V2
Links	- -
Type	protein
Relations	1
Function	Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).