Summary

Name IL22RA1
Full Name Interleukin-22 receptor subunit alpha-1
Synonyms IL-22 receptor subunit alpha-1, IL-22R-alpha-1, IL-22RA1, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, CRF2-9, ZcytoR11 | IL22R
Primary ID Q8N6P7
Links - -
Type protein
Relations 7
Function Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

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Relations

Regulator Mechanism target score ℹ
+ IL22RA1up-regulates img/indirect-activation.png STAT3 0.638
Publications: 1 Organism: Homo Sapiens
+ Cullin 1-RBX1-Skp1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination IL22RA1 0.2
Publications: 1 Organism: In Vitro
+ FBXW12down-regulates quantity by destabilization img/direct_inhibition.png binding IL22RA1 0.348
Publications: 1 Organism: In Vitro
+ IL22RA1up-regulates img/direct-activation.png binding JAK1 0.504
Publications: 1 Organism: Homo Sapiens
+ IL22up-regulates img/direct-activation.png binding IL22RA1 0.89
Publications: 1 Organism: Homo Sapiens
+ IL22RA1up-regulates img/direct-activation.png binding TYK2 0.524
Publications: 1 Organism: Homo Sapiens
+ IL20up-regulates img/direct-activation.png binding IL22RA1 0.59
Publications: 1 Organism: Homo Sapiens