| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization 
polyubiquitination
|
IL22RA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272428 |
|
|
in vitro |
|
| pmid |
sentence |
| 26171402 |
FBXW12 causes depletion of endogenous and plasmid-derived IL-22R in lung epithelia, binds the E3 ligase constituent Skp-1, and facilitates ubiquitination of IL-22R in vitro. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FBXW12 | down-regulates quantity by destabilization
binding
|
IL22RA1 |
0.347 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272426 |
|
|
in vitro |
|
| pmid |
sentence |
| 26171402 |
FBXW12 causes depletion of endogenous and plasmid-derived IL-22R in lung epithelia, binds the E3 ligase constituent Skp-1, and facilitates ubiquitination of IL-22R in vitro. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
IL22RA1 | up-regulates 
binding
|
JAK1 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124489 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15120645 |
Each r1-type chain (il-10r1, il-20r1, il-22r1, ifn-_r1 and ifn-_r1) is associated with jak1 tyrosine kinase and mediates recruitment of a variety of signaling molecules after being phosphorylated on its intracellular domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL22RA1 | up-regulates
binding
|
TYK2 |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90165 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12087100 |
Il-22 activates jak1 and tyk2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL20 | up-regulates
binding
|
IL22RA1 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151877 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11163236 |
An IL-20 receptor was identified as a heterodimer of two orphan class II cytokine receptor subunits. Both receptor subunits are expressed in skin and are dramatically upregulated in psoriatic skin. Taken together, these results demonstrate a role in epidermal function and psoriasis for IL-20, a novel cytokine identified solely by bioinformatics analysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL22 | up-regulates
binding
|
IL22RA1 |
0.891 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86340 |
|
|
Homo sapiens |
T-lymphocyte, Monocyte |
| pmid |
sentence |
| 12941475 |
In addition, il-22 mediates inflammation and binds class ii cytokine receptor heterodimers il-22 ra1/crf2-4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL22RA1 | up-regulates 
|
STAT3 |
0.642 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90162 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12087100 |
Il-22 also induced serine phosphorylation of stat3 on ser(727). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IL22RA1
- 
- 