Summary

Name ARFGAP1
Full Name ADP-ribosylation factor GTPase-activating protein 1
Synonyms ARF GAP 1, ADP-ribosylation factor 1 GTPase-activating protein, ARF1 GAP, ARF1-directed GTPase-activating protein | ARF1GAP
Primary ID Q8N6T3
Links - -
Type protein
Relations 5
Inhibitors (2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol
Function GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ ARFGAP1up-regulates img/direct-activation.png binding LRRK2 0.598
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ (2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanoldown-regulates activity img/direct_inhibition.png chemical inhibition ARFGAP1 0.8
Publications: 1 Organism: Homo Sapiens
+ LRRK2down-regulates img/direct_inhibition.png phosphorylation ARFGAP1 0.598
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ ARFGAP1up-regulates activity img/direct-activation.png gtpase-activating protein ARF1 0.858
Publications: 1 Organism: In Vitro