Summary

Name ARF1
Full Name ADP-ribosylation factor 1
Synonyms ARF1_HUMAN |
Primary ID P84077
Links - -
Type protein
Relations 5
Function GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).; FUNCTION

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Relations

Regulator Mechanism target score ℹ
+ ARF1up-regulates img/indirect-activation.png Vesicle_transport 0.7
Publications: 1
+ GBF1up-regulates activity img/direct-activation.png guanine nucleotide exchange factor ARF1 0.709
Publications: 1 Organism: Chlorocebus Aethiops
+ ARFGAP1up-regulates activity img/direct-activation.png gtpase-activating protein ARF1 0.858
Publications: 1 Organism: In Vitro
+ ASAP2up-regulates activity img/direct-activation.png gtpase-activating protein ARF1 0.641
Publications: 1 Organism: In Vitro
+ ARFGEF1up-regulates activity img/direct-activation.png guanine nucleotide exchange factor ARF1 0.584
Publications: 1 Organism: Homo Sapiens