Summary

Name JMY
Full Name Junction-mediating and -regulatory protein
Synonyms JMY_HUMAN |
Primary ID Q8N9B5
Links - -
Type protein
Relations 2
Function Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding ARP2/3 0.318
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding JMY 0.51
Publications: 1 Organism: Homo Sapiens