Summary

Name NAT8L
Full Name N-acetylaspartate synthetase
Synonyms NAA synthetase, Camello-like protein 3, N-acetyltransferase 8-like protein | CML3
Primary ID Q8N9F0
Links - -
Type protein
Relations 4
Pathways Aspartate and asparagine metabolism
Function Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake.

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Relations

Regulator Mechanism target score ℹ
+ NAT8Ldown-regulates quantity img/direct_inhibition.png chemical modification acetyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ NAT8Ldown-regulates quantity img/direct_inhibition.png chemical modification L-aspartate(1-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ NAT8Lup-regulates quantity img/direct-activation.png chemical modification coenzyme A(4-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ NAT8Lup-regulates quantity img/direct-activation.png chemical modification N-acetyl-L-aspartate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism