| + |
SUN1 | up-regulates activity 
binding
|
TERB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263299 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 33015044 |
In this study, we found that SUN1 not only interacted with TERB1 but also interacted with MAJIN, and the interaction of SUN1 with MAJIN is stronger than TERB1. We also found that SUN1 interacted with SPDYA, an activator of CDK2. | It will be of great interest to test this hypothesis to fully understand the mechanisms of stable telomere–NE connection and telomere movement along the NE driven by the LINC complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TERB1 | form complex 
binding
|
TTM complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263302 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 30718482 |
Meiotic specific proteins TERB1, TERB2, and MAJIN form a stable complex that plays a critical role in regulating the recruitment of telomeres to the NE |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TERB1 | up-regulates activity
relocalization
|
TERF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263315 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 33015044 |
The shelterin complex has six proteins, containing TRF1, TRF2, POT1, RAP1, TIN2, and TPP1. The shelterin complex is localized to the chromosome end and protects telomeric DNA (Palm and de Lange, 2008). The TTM complex acts as a “linker” and bridges the LINC and shelterin complexes together. The connection between TTM and shelterin complexes is well-known, which is mediated by TERB1 and TRF1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TERB1
- 
- 