3.0
Summary
| Name |  TERF1View Modifications |
| Full Name | Telomeric repeat-binding factor 1 |
| Synonyms | NIMA-interacting protein 2, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1 | PIN2, TRBF1, TRF, TRF1 |
| Primary ID | P54274 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NEK7 | up-regulates quantity by stabilization 
phosphorylation
|
TERF1 | 0.348 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATM | up-regulates activity
phosphorylation
|
TERF1 | 0.59 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PLK1 | up-regulates
phosphorylation
|
TERF1 | 0.382 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK2A1 | up-regulates
phosphorylation
|
TERF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCAPH2 | up-regulates activity
binding
|
TERF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TERF1 | form complex 
binding
|
Shelterin complex | 0.743 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TNKS | down-regulates activity 
ADP-ribosylation
|
TERF1 | 0.796 |
| Publications: | 1 | Organism: | In Vitro | |
| + | TERB1 | up-regulates activity
relocalization
|
TERF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TNKS2 | down-regulates activity
ADP-ribosylation
|
TERF1 | 0.567 |
| Publications: | 1 | Organism: | In Vitro | |