3.0
Summary
| Name |  HJURPView Modifications |
| Full Name | Holliday junction recognition protein |
| Synonyms | 14-3-3-associated AKT substrate, Fetal liver-expressing gene 1 protein, Up-regulated in lung cancer 9 | FAKTS, FLEG1, URLC9 |
| Primary ID | Q8NCD3 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT | up-regulates activity 
phosphorylation
|
HJURP | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | 14-3-3 | up-regulates activity
binding
|
HJURP | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | HJURP | up-regulates activity
binding
|
CENPA | 0.958 |
| Publications: | 1 | Organism: | Homo Sapiens | |