Summary

Name CCNY
Full Name Cyclin-Y
Synonyms Cyc-Y, Cyclin box protein 1, Cyclin fold protein 1, cyclin-X | C10orf9, CBCP1, CFP1
Primary ID Q8ND76
Links - -
Type protein
Relations 9
Function Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ AMPKup-regulates activity img/direct-activation.png phosphorylation CCNY 0.2
Publications: 1 Organism: Homo Sapiens
+ PRKAA1up-regulates activity img/direct-activation.png phosphorylation CCNY 0.2
Publications: 1
+ CyclinY/CDK14down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CCNY 0.824
Publications: 2 Organism: Homo Sapiens
+ CDK14down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CCNY 0.824
Publications: 2 Organism: Homo Sapiens
+ CCNYform complex img/form-complex.png binding CyclinY/CDK16 0.691
Publications: 1
+ CCNYup-regulates img/direct-activation.png binding CDK14 0.824
Publications: 1 Organism: Homo Sapiens
+ CCNYform complex img/form-complex.png binding CyclinY/CDK14 0.824
Publications: 1